Any enzyme of interest

immobilized onto safe silica nanoparticles

shielded with a soft and porous layer of functionalized silica

finished with a fully biocompatible coating

Enzyme shielded in a soft and porous functionalized silica layer

Large antibodies are not exposed to the enzyme -> much lower immunogenicity

Substrates freely access the enzyme -> full activity and enhanced stability in the layer
No release mechanism

Patent WO2015/014888
Publications: RSC Adv., 2016, 6, 89966;  Angew. Chem. Int. Ed. 2016, 55, 6285

Highly versatile platform technology with easily tunable size, structure, properties, applicable to any enzyme of therapeutic interest

The end product (patentable) is a bioactive nanomedicine (see picture below) with a fully active, stabilized, yet not exposed enzyme embedded in the layer, which enables the substrate to access the enzyme active site and react.

Partner’s enzyme of interest

  • Well characterized
  • Proven
  • Patented

  • Fully customizable
  • Highly reproducible
  • Cost-effective

  • New Medical Entity
  • Best-in-class
  • Improved Immunogenicity
  • Improved stability
  • New patent
  • Freedom to Operate